The VSD conducts vaccine safety studies based on questions or concerns raised from the medical literature and reports to the Vaccine Adverse Event Reporting System (VAERS) and other vaccine safety systems. This vaccine safety system also uses information about medical illnesses that have been diagnosed at doctors’ offices, urgent care visits, emergency department visits, and hospital stays to help monitor the safety of vaccines. The VSD collects information about the kind of vaccine given to each patient, the date of vaccination, and other vaccinations given on the same day. The VSD uses electronic health data from participating sites to monitor and assess the safety of vaccines. As of September 28, 2022, there are 13 VSD sites that provide clinical, methodological, and data expertise 11 currently are data-providing sites and the remaining sites provide subject matter expertise. The VSD started in 1990 and continues today to monitor the safety of vaccines and conduct studies about rare and serious adverse events following immunization. The Vaccine Safety Datalink (VSD) is a collaborative project between CDC’s Immunization Safety Office, integrated healthcare organizations, and networks across the United States.
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